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10.1007/s00125-006-0340-2 117 MatsuiT.NishinoY.TakeuchiM.YamagishiS

An appreciation of the potency of GLP-1R agonists for weight loss has led to the rapid development of agents that combine GLP-1R agonism with agonism at other receptors to enhance their efficacy for weight loss and other metabolic outcomes

Increasingly, the medical community and the general public understand obesity to be a chronic, relapsing illness, as opposed to an overall moral failure