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These platforms enable on-demand insulin or GLP-1 release triggered by elevated blood glucose levels, providing a closed-loop feedback mechanism that enhances therapeutic precision and reduces the risk of hypoglycemia [41]

24 A more recent double-blind, randomized, controlled trial that investigated the microvascular effects of linagliptin in nondiabetic patients with arterial hypertension resulted in a significant improvement in retinal capillary perfusion and retinal arterial blood flow

About this article Cite this article Wolff Sagy, Y., Lavie, G., Ramot, N