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Although these data are necessary and informative, it will be critical to better understand whether analogous effects are observed within a narrower window of changing leptin levels, as may occur during alterations of energy state or development in fed versus fasted states (RamosLobo et al., 2019)

The release of proglucagon causes the liver to make glucose (gluconeogenesis converting protein to glucose) as well as to convert fatty acids into ketone bodies

Symptoms appear within the first few weeks, peak during weeks 6-8 (coinciding with dose escalation), and resolve substantially by week 12

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