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Dehydration risk increases if you experience gastrointestinal side effects like nausea or reduced appetite for water-rich foods

Despite the therapeutic advantages offered by GLP-1 RAs, concerns have emerged regarding their potential association with an increased risk of pancreatitis [4,5,6]

This hypothalamus/hindbrain focused model of GLP-1 action, however, does not easily accommodate the recent findings showing that GLP-1R stimulation reduces food reward behavior (Dickson et al., 2012)

This rapid initial rebound is why abrupt discontinuation is generally less successful than planned tapering or continuous therapy