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Some experts believe that cerebral IR is the result of ceramide accumulation in brain tissue, and ROS overproduction occurs due to metabolic abnormalities accompanying peripheral IR and impaired mitochondrial activity in the IR brain.13 Studies have shown that ROS can cause age-related synaptic loss and ultimately cognitive impairment,42 where ROS interactions with inflammation may play a role

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En parallle, une tude de phase 2a a valu l'effet sur la statose hpatique associe un dysfonctionnement mtabolique (MASLD) : 12 mg, une rduction de la teneur en graisse hpatique de 86 % a t atteinte, et 93 % des participants ont normalis leur teneur en graisse hpatique en dessous de 5 % (Sanyal et al., 2024)