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Research on the traits of gut microbiota in T2DM patients who are either tolerant or intolerant to metformin showed that alterations in gut microbiota composition following metformin therapy play a role in drug intolerance (Daz-Perdigones et al., 2022)
doi: 10.1056/NEJMoa2302392 [DOI] [PubMed] [Google Scholar] 200.Newsome PN, Buchholtz K, Cusi K, et al
Glucagon-like peptide-1 receptor agonists use for type 2 diabetes mellitus in end-stage renal disease
There are also no FDA-approved drug products containing berberine, the agency adds
