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We also used a self-controlled case series design [19], which comprised of new users of GLP-1 RAs ( n = 85,717 ) or SGLT-2 inhibitors ( n = 78,366 ) or DPP-4 inhibitors ( n = 35,762) from 2014 to 2022

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The potential mechanism of GLPs action in IBD may include promotion of tissue repair of injured epithelium, regulation of T cell differentiation and functions, regulation of innate immune cells such as macrophages and dendric cells, and reduction of proinflammatory cytokines (Fig

For Patients and Clinicians Ongoing pharmacovigilance is critical: patients must stay informed about label changes , potential side effects, and emerging clinical evidence