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(2018) GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential underlying mechanisms

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Izervay is a PEGylated oligonucleotide that works by targeting and disabling the C5 complement protein, thus addressing an underlying cause of age-related macular degeneration (AMD)

In people with established CVD, a GLP-1 RA with proven benefit should be used to reduce MACE, or an SGLT2i with proven benefit should be used to reduce MACE and HF and improve kidney outcomes