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Clinical evidence suggests approximately 5mg of tirzepatide may produce similar glycemic effects to 2mg of semaglutide, though individual variation is substantial and requires provider oversight
As a precaution, people with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2 syndrome should not use GLP-1 RA [enttoday.org, droracle.ai]
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This suggests the effect isn't just a short-term adaptation but a sustained physiological response to the compound
