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Description
People who experienced significant wearing-off on semaglutide often find the effect more noticeable after switching to tirzepatide, not because tirzepatide is less effective, but because its shorter half-life creates a wider gap between peak and trough levels
The discomfort signals that the stimulus is working, not that something is wrong
Patients may discontinue treatment due to the inability to tolerate these side effects
Target 80-100 ounces of water daily
