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Description
The evolution of the GLP-1RA class to include an oral agent could facilitate the use of these agents earlier in the diabetes treatment cascade owing to wider acceptance from patients and healthcare professionals
Potency test
Instead of weekly injections like humans receive, the cats in the study will get small injectable implants, slightly larger than a microchip, that release the drug gradually over six months
Interestingly, kinome analysis of mouse islets demonstrated that an acute treatment with exendin 4 increased pRb phosphorylation and subsequent E2f1 transcriptional activity
