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For example, in ApoE-deficient mice, GIP analogs significantly reduced atherosclerosis and improved vascular function ( 5.2 Prospective clinical trial progress and results of tirzepatide in the treatment of type 2 diabetes with cardiovascular disease Currently, two significant cardiovascular outcome trials for tirzepatide are underway (or have recently concluded), including SURPASS-CVOT and SUMMIT

More relevant to weight management, these agents act on receptors in the brain's appetite centers, particularly the hypothalamus, reducing hunger signals and increasing satiety after meals

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GIP promotes clearance of circulating triglycerides and free fatty acids and enhances adipose tissue triglyceride absorption, serving as a crucial hormonal regulator of postprandial triglyceride response in humans (173175)