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JAMA , 314 (7), 687699

Main Studies and Results of Semaglutide for Weight Loss The early clinical trials of SMG (phase 2 and phase 3a) were designed to determine the optimal dose of subcutaneous SMG compared to placebo or liraglutide [59] and to assess the safety and efficacy of both subcutaneous and oral SMG compared to placebo [60] in individuals with DM2

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For confirmed orthostatic hypotension, healthcare professionals may recommend compression stockings or dietary salt adjustments as part of an individualised treatment plan