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Sequence modification to enhance DPP-4 resistance combined with covalent attachment of a fatty acid leads to slower absorption and mediates albumin binding in plasma, a strategy employed in the development of the once-daily and once-weekly agents, Victoza and Ozempic, respectively
Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective

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Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
