glp 1 agonist saxenda GLP-1 analogs, new trend in obesity treatment, become even more effective < Pharma < Article Saxenda (liraglutide)

The main action of GLP-1 is to maintain postprandial glucose homeostasis by enhancing insulin secretion and inhibiting glucagon secretion

Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]

Fifth, GLP-1RAs protect against cardiomyocyte apoptosis under diabetic conditions via activating the leucine zipper motif (APPL 1 )-AMPK-PPAR axis and the AMPK-TXNIP pathway [80, 161]

16 Particularly the effects of these medications have covered importance in diseases closely related to obesity and DM such as CKD, cardiovascular disease and MASH