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Description
Intrathecal injection of exendin-4 reduced pain sensitivity as assessed by the von Frey test and decreased neuroinflammation, with reduced TNF, IL-1 and IL-6 levels, thus demonstrating that analgesic effects of GLP-1R signalling were directly correlated with its anti-neuroinflammation activity [89]
[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Kabahizi A., Wallace B., Lieu L., Chau D., Dong Y., Hwang E.S., Williams K.W
How Long Does Metformin Take to Work
Most patients benefit from a long-term maintenance strategy to prevent weight regain and protect metabolic health
