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Almost comparable to whats seen with some surgical interventions: Participants lost up to 20.9% of their body weight on the highest dose (15 mg) 91% lost at least 5% of their body weight More than half lost 20% or more, and over a third dropped 25% or more Waist size, blood pressure, insulin resistance, and cholesterol all improved Most side effects (like nausea or constipation) were mild and appeared mostly during the dose adjustment phase

Its unknown whether the same will be seen in humans, but semaglutide is not recommended for anyone with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

While this number must be contextualized against the millions of doses administered, it underscores that quality control issues in compounded products are not hypothetical