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Bacterial diversity measured at the species level did not change significantly following liraglutide and GUB09-145 treatment, which indicates that drug treatment effects on gut microbiome signatures in DIO mice were attributed to re-arrangement of low-abundant species

Furthermore, GLP-1 receptor agonists induce anti-inflammatory effects that could attenuate the low-grade inflammation that underlies obesity, PsO, and HS (reviewed recently in the context of PsO and psoriatic arthritis).68 Finally, improved metabolic control and cardio-renal protection could be beneficial for reducing CVR and managing comorbidities such as DT2 or metabolic syndrome

53 Chaudhuri et al 32 found that 12-week treatment with exenatide for diabetic patients suppressed the generation of reactive oxygen species and the intranuclear NF-B binding by mononuclear cells