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GLP-1s and SGLT2s: The New Power Players in Diabetes Care By 2024, more Medicare patients with T2D are sticking with GLP-1 or SGLT2 therapies as their sole treatment, doubling since 2020

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However, three subsequent randomized control trials reported a neutral effect in airway inflammation with both available TZDs, pioglitazone and rosiglitazone

While not a formal contraindication, clinicians generally defer initiation of tirzepatide until patients with hyperthyroidism are euthyroid, as overlapping symptoms and cardiovascular effects could complicate assessment of medication tolerance and efficacy