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This happens because semaglutide activates GLP-1 receptors in your brain's appetite control centers, slowing gastric emptying and signaling satiety to your central nervous system
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doi: 10.1016/j.ejphar.2011.03.024

Many women report meaningfully different hunger suppression patterns on retatrutide compared to tirzepatide, with particularly strong effects on food reward and cue-triggered eating rather than just basal appetite