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Both medications contain the active ingredient which also mimic the naturally occurring gastrointestinal hormone GLP-1 but also mimics the GI hormone gastric inhibitory peptide (GIP)

Recommended Tesofensine Dosage Strategy A safe and effective approach usually looks like this: Start at 0.25 mg daily to assess tolerance After 46 weeks, increase to 0.5 mg daily if needed 1.0 mg may be considered for select patients under close medical monitoring Morning dosing can help avoid insomnia

Different mechanisms, different side-effect profiles

Waj Mehal is a professor of medicine at Yale School of Medicine, an obesity medicine doctor and director of the Fatty Liver Program and Yale Metabolic Health and Weight Loss Program