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For the future of metabolic therapeutics, survodutide's dual mechanism targeting both caloric intake and energy expenditure could prove transformative if Phase 3 data confirm the Phase 2 promise

An injectable hydrogel system, Diabogel, has been developed using alginate and 3-aminophenylboronic acid to deliver modified GLP-1, islet-derived extracellular vesicles, and telmisartan

Common side effects include: Gastrointestinal: Nausea, diarrhea, constipation, and abdominal pain (most common, usually transient) Decreased appetite: Expected and generally beneficial for weight management Injection site reactions: Mild redness or irritation at the injection site Rare but serious risks include: Pancreatitis (inflammation of the pancreas seek immediate medical attention for severe abdominal pain) Gallbladder disease Potential thyroid tumor risk (based on animal studies

wrote the manuscript with inputs from all co-authors