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In addition to efficacy and safety data, clinicians should also consider patient preference for the administration device, as it is an important driver of the choice of medication

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If you notice hair loss while using any of these medicines, or if you are losing weight more rapidly than expected, contact your healthcare provider
much lower at community doses Vomiting up to 36% at high doses Diarrhea 23-26% Constipation 17-19% Fatigue 11-13% Pancreatitis risk trials flagged severe abdominal pain for discontinuation and evaluation Gallbladder issues rapid weight loss increases gallstone risk Thyroid C-cell tumors same boxed warning as semaglutide (animal studies) GI side effects were more intense than semaglutide in trial data due to the dual mechanism
