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Description
The small molecule has a strong affinity for the GIP receptor and inhibition of GIP-stimulated cAMP production in vitro ( Table 1 )

Generally, long-acting agents have been associated with greater cardiovascular benefits than short-acting ones (Table 2)

Metabolic risk in patients with IBD While evidence remains mixed regarding the direct impact of obesity on IBD disease activity, the literature consistently demonstrates that obesity is associated with an increased risk of surgical complications, 104 particularly post-operative infections where a systematic review found an odds ratio of 1.48 compared to non-obese patients with IBD, technical challenges in the creation of an ileal pouchanal anastomosis or stoma 105 and parastomal hernia development

Microdosing is an off-label use of GLP-1 medications and is not FDA-approved for the indications discussed herein
