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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes

Blood sugar management at the starting dose is generally favorable, but coordination with a healthcare provider who manages diabetes medications is important to prevent hypoglycemic events as retatrutide begins improving insulin sensitivity

However, losing as little as 5% of body weight can have health benefits

At the time the protocols were finalized, trial results for SURPASS-CVOT were not yet available