tirzepatide cardiac benefits Variable weight-loss and cardiovascular were seen with GLP-1 drugs in a systematic review and network meta-analysis, but effects on quality of life were less clear. https://www.medpagetoday.com/primarycare/obesity/122142 How Tirzepatide Supports Cardiovascular Health
Description
If these medications are co-prescribed, thyroid function should be monitored, and patients should discuss with their healthcare provider about appropriate timing of each medication

That may not necessarily be the case
The first significant factor identified was the duodenal glucose-dependent insulinotropic polypeptide, GIP, which however, turned out not to stimulate insulin secretion in patients with type 2 diabetes

Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects
