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single-use aliquoting before long-term storage is the recommended protocol in research settings

Other AEs reported with SGLT2i use include osmotic diuresis-related events and volume depletion-related hypotension, the latter of which tends to be more common in older adults, people with an eGFR of 3060 mL/min/1.73 m 2 , and in those taking loop diuretics [4]

Underpotent product, degraded medication from improper storage, or formulations with poor sublingual absorption characteristics can all produce disappointing results at doses that should be effective

This suggests that while the warning is in place due to animal data, the actual risk in humans appears to be minimal based on current evidence