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3a, b, Supplementary Fig
Metabolic Health: By improving insulin sensitivity and controlling blood glucose, GLP-1 agonists support better overall metabolic health and reduce the risk of long-term health issues
Relafen (nabumetone): Relafen is approved to treat pain and inflammation caused by rheumatoid arthritis and osteoarthritis
Switching to tirzepatide, which activates both GLP-1 and GIP receptors (two appetite-control pathways instead of one), can overcome this resistanceapproximately 15-20% of patients respond better to dual-pathway activation
