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When you lose weight through any method (surgery, medication, or lifestyle), your body reduces metabolic rate to defend against further weight loss

Comprehensive support: Many programs include nutrition, lifestyle, and behavioral coaching alongside medication

In addition, weight loss was less pronounced in people with DM2, and long-term cardiovascular safety data in obese populations remain limited

The difference in HbA1c-lowering effects of oral semaglutide between our study and previous trials [8, 26, 37, 44] may be partly due to the fact that our patients were already receiving treatment with DPP-4 inhibitors and had lower baseline HbA1c values than those in the PIONEER trials