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That frustration has led both patients and clinicians to look beyond the existing toolkit and increasingly toward a newer class of drugs

264 In addition, microglia lacking DJ-1 showed increased mitochondrial activity, leading to elevated levels of ROS compared to normal microglia, and this effect was further increased by treatment with LPS

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Some patients on gabapentin may experience slightly delayed pain relief initially due to semaglutide's gastrointestinal effects, but this typically resolves within 23 weeks as tolerance develops