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Keywords: ketogenic Mediterranean diet, metabolic adaptation, adaptive thermogenesis, personalized nutrition, weight loss maintenance, obesity management, GLP-1 receptor agonists, dynamic dietary protocols, nutritional ketosis Abstract Background/Objectives: Long-term obesity management consistently fails due to two major barriers: poor adherence, exacerbated by ultra-processed foods with addictive potential, and post-weight loss metabolic adaptation that reduces energy expenditure by approximately 500 kcal/day