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Combination therapy is typically considered when monotherapy or dual therapy with other agents (such as metformin) fails to achieve adequate glycaemic targets, or when patients require additional cardiovascular or renal protection

The following strategies can help patients maintain energy levels during treatment

Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes

Finally, we highlight knowledge gaps in the present understanding of GLP-1RA treatment of BAD and outline the needs for further clinical evidence generation
