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In the STEP UP clinical trial, the 7.2 mg dose produced a mean weight loss of 20.7% at 72 weeks, compared with 17.5% at the previously approved 2.4 mg dose and 2.4% with placebo

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Eli Lilly, Novo Nordisks main rival in diabetes and weight loss drugs, still holds its patent in Canada for Mounjaro and Zepbound and faces no imminent patent expiry here

In Phase 2 clinical trials, retatrutide was administered as a once-weekly subcutaneous injection , following a structured dose escalation protocol designed to minimise gastrointestinal side effects whilst optimising efficacy