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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder
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Patients in the dose-escalation phase have increased risk of gastric emptying delay, and this phase often lasts four to eight weeks
To investigate the physiological functions of endogenous GLP-1 mediated via vagal sensory neurons, a rat model with vagal sensory neuron-specific GLP-1R knockdown was generated by microinjecting a viral vector expressing GLP-1R shRNA into the nodose ganglion [51]