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In most cases, treating adrenal insufficiency is much simpler than treating hypercortisolism. Osilodrostat-associated Adrenal Gland Shrinkage: A Case Series of Patients With ACTH-dependent Cushings Syndrome , by Elena V
Additionally, gastrointestinal tolerability affects real-world effectivenessnausea, the most common adverse effect, may limit dose escalation in some individuals, potentially reducing the achievable HbA1c reduction
Due to its action on the central nervous system, tesofensine should be used cautiously, especially by individuals with pre-existing cardiovascular conditions
