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Description
It only got its first formal clinical definition in 2025, but people on GLP-1 medications have described the change for years: for many, the noise fades within the first weeks and dose steps, and that quiet is often the most life-changing effect

The buildup creates discomfort
They took the time to answer all of my questions and called last week to see how I was doing after the first week

Obesity as a multisystem disease: trends in obesity rates and obesity-related complications
