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Low), and in individuals with T2DM (Class IV
Extended Data Figure 4 Effects of binding pocket mutations on potency of NAMs

Potential future applications in microbiome-personalized diabetes care may be supported by a few early studies that also indicate the baseline microbiota composition may predict the extent of the metabolic response to GLP-1RAs, suggesting that treatment of diabetes in a microbiome-specific manner should be explored [3, 12]

16.Wilding JPH, Batterham RL, Calanna S, et al
