pancreatitis and glp-1 Risk Associated with Receptor Agonists, Considered as a Single Class, in a Comorbidity-Free Subgroup of Type 2 Diabetes Patients in the United States: A Propensity Score-Matched Analysis Updates in Medicine | GLP-1s
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Such medications risk suppressing appetite excessively, which can potentially lead to conditions mimicking Avoidant/Restrictive Food Intake Disorder (ARFID)

DPP-4 can also have signaling functions via interactions with the extracellular matrix (90), and it was therefore speculated that the DPP-4 inhibitor might have improved insulin sensitivity by interfering with this process in some way rather than by blocking the enzymatic activity per se (79, 89)