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In that context, a 16% benefit is a big deal. He notes that these findings were among patients at high risk for a cardiovascular event and may not apply to lower-risk populations

Changes in cardiometabolic risk markers from baseline to 12 months were evaluated including blood pressure, fasting glucose, HbA1c, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides

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Food and Drug Administration (FDA), the most commonly reported side effects of these medications include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, bloating, belching, and flatulence