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Description
Treating HFpEF is a lot harder than treating HFrEF

The full effect lands around month 6 (26 weeks), which was the primary endpoint in the FDA approval trials

In consistently slow gastric emptying, switching from rapid-acting insulin analogues to regular human insulin may be beneficial, as its slower onset (3060 min) and longer duration (68 h) can better match the delayed absorption of carbohydrates [3, 14, 92, 113, 114]

Dosing starts at 5 mg per day and may gradually increase to 10 mg daily
