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Accordingly, culturing human islets in the presence of a DPP-4 inhibitor resulted in increased levels of intact GLP-1 (98, 101, 104), increased insulin secretion (98, 99, 101, 104), and improved -cell survival (99, 101)

GLP1/E, at very low doses, is sufficient to ameliorate PCOS-associated metabolic alterations Since GLP1/E was superior to any other compound in terms of improvement of metabolic traits, we next assessed the metabolic efficacy of very low doses of this multi-agonist in our metabolically dysregulated PCOS model

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Studies in mechanisms showed that exenatide treatment influenced the expression of key markers associated with ER stress [66]