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87 Specifically, activation of Takeda G-protein-coupled receptor 5 (TGR5) by bile acids stimulates GLP-1 release from intestinal L cells

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[1] In clinical practice the transdermal estradiol system is most often prescribed for the treatment of moderate to severe vasomotor symptoms such as hot flashes and night sweats, for the prevention of postmenopausal osteoporosis in women at significant fracture risk who cannot tolerate or have contraindications to alternative therapies, and as replacement therapy in individuals with primary ovarian insufficiency or oophorectomy where endogenous estrogen is deficient