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Back McLean, BA, Wong, CK, Campbell, JE, et al (2021) 'Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation', Endocrine Reviews , 42/2, 101-32
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Taken together, metformin may upregulate PKA signalling to exert its synergistic protective effects with liraglutide in both GLP-1R-dependent and -independent manners in PA-impaired endothelial cells
In a Lilly-funded trial comparing Foundayo to Rybelsus, patients with type 2 diabetes on 12 to 36 milligrams of orforglipron lost 15 to 20 pounds on average, while those on 7 to 14 milligrams of Rybelsus lost 8 to 11 pounds
