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8 Indeed, the primary determinant of LR is impaired responsiveness or reduced sensitivity of the brain to leptin, which is attributed to altered function in BBB transport mediated by short isoforms of LEPR (i.e., LEPR-a, LEPR-b, LEPR-c)

TolhurstGHeffronHLamYSParkerHEHabibAMDiakogiannakiEet al

A cohort study result indicates that weekly doses of 1.7 mg and 2.4 mg of semaglutide led to weight loss comparable to that observed in randomized clinical trials

While initially approved for glucose control, these agents have shown pleiotropic benefits, including cardiovascular risk reduction, weight loss, renal protection and anti-inflammatory effects, among others [6]
