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For example, the FDA has approved the following drugs when combined with diet and exercise: Wegovy and Zepbound (trade names) to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults who are overweight and have at least one weight-related condition

The role of HN and MOTS-c in T1DM has been investigated using the non-obese diabetic (NOD) mouse model of the disease

Implications for Obesity Treatment Policy Tirzepatide appears to be a cost-effective option with favorable modeled clinical outcomes compared to semaglutide for managing obesity and overweight in the U.S