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15 Bariatric surgery Bariatric surgery is a highly effective treatment for obesity, often leading to more pronounced and sustained weight loss than GLP-1 RAs (mean difference: 22.7 kg, 95% CI 31.4, 14.0) 16 and pharmalogical treatment as a whole (22.1 kg, 95% CI 28.9, 15.2)

While often temporary and most pronounced during dose escalation, semaglutide-related nausea can significantly impact quality of life
