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In adverse event reports, alogliptin was associated with 3 cases of biliary malignancies, linagliptin with 9 cases, and their 95%CI for ROR and EBGM05 exceeded the signal detection thresholds, indicating a possible statistically significant correlation

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PPG neurons in the nucleus tractus solitarius (PPG NTS neurons) suppress eating when chemogenetically or optogenetically activated 57 , consistent with substantial pharmacological evidence for anorexigenic GLP-1 signalling in the brain (reviewed by Muller et al 4 )

The oral route means the medication passes through the GI tract rather than being injected subcutaneously, which could alter the pharmacokinetic profile and potentially influence which side effects are more or less prominent