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Some gastroenterologists have successfully managed patients on GLP-1s by starting with lower doses, monitoring symptoms closely, and adjusting the treatment plan as needed

An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases

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Together, these results suggest that enhanced alpha-cell GLP-1 production may be an early response to metabolic dysregulation, suggesting that the adaptation to metabolic stress involves a greater reliance on this intra-islet paracrine signaling for glucose homeostasis