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Digestive Changes and Gut Health GLP-1 medications slow gastric emptying, which can lead to: Constipation Reduced bowel frequency Bloating Dietary adjustments can help manage these effects safely

Risk factors and systemic comorbidities HS is characterized by a complex and multifactorial etiology involving genetic predisposition, environmental triggers (i.e., stress), and behavioral factors (alcohol consumption, smoking), with a higher prevalence in women (ratio Female:Male 3:1) [22] (Fig

[5] This rapid breakdown explains why therapeutic GLP-1 receptor agonists have been chemically modified to resist DPP-4 degradation, thereby extending their duration of action and clinical efficacy in managing diabetes and obesity

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