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its that the price of breakthrough therapies across the board has been climbing for years
Mice given 0.4 mg/Kg GLP-1 showed better colon protection effect (increased colon length and decreased inflammatory cytokine secretion) than mice given 0.1 and 0.2 mg/Kg GLP-1 at low and medium doses, but no difference in weight loss
To validate these bioinformatic findings, we performed RTPCR to examine HippoYAP pathway activity in an obese mouse model and in vitro coculture systems that mimic an obesityrich microenvironment (Figure 1M,N)
2024 doi: 10.1016/j.cgh.2024.10.003
